Many gene defects are relatively easy to identify experimentally, but obtaining information
about the effects of sequence variations and elucidation of the detailed molecular …

Unlike random heteropolymers, natural proteins fold into unique ordered structures.
Understanding how these are encoded in amino-acid sequences is complicated by …

Geometrical validation around the C is described, with a new C measure and updated
Ramachandran plot. Deviation of the observed C atom from ideal position provides a single …

Structural genomics projects are providing large quantities of new 3D structural data for
proteins. To monitor the quality of these data, we have developed the protein structure …

Protein NMR chemical shifts are highly sensitive to local structure. A robust protocol is
described that exploits this relation for de novo protein structure generation, using as input …

The fact that natural β-sheet proteins are usually soluble but that fragments or designs of β
structure usually aggregate suggests that natural β proteins must somehow be designed to …

Online citizen science projects such as GalaxyZoo, Eyewire and Phylo have proven very
successful for data collection, annotation and processing, but for the most part have …

Traditional methods for macromolecular refinement often have limited success at low
resolution (3.0–3.5 Å or worse), producing models that score poorly on crystallographic and …

A powerful feature of macromolecular structure analysis by NMR spectroscopy is its potential
for automation. 1, 2 It has been recognized for some time that many of the interactive tasks …

Surprisingly, the frozen structures from ultra-high-resolution protein crystallography reveal a
prevalent, but subtle, mode of local backbone motion coupled to much larger, two-state …