Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response
Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
[HTML][HTML] Role of the mechanical microenvironment in cancer development and progression
Q Liu, Q Luo, Y Ju, G Song - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …
Two-way communication between ex vivo tissues on a microfluidic chip: application to tumor–lymph node interaction
Experimentally accessible tools to replicate the complex biological events of in vivo organs
offer the potential to reveal mechanisms of disease and potential routes to therapy. In …
offer the potential to reveal mechanisms of disease and potential routes to therapy. In …
Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system
To study how cancer cells can withstand fluid shear stress (SS), we isolated SS-resistant
breast and lung cancer cells using a microfluidic circulatory system. These SS-resistant cells …
breast and lung cancer cells using a microfluidic circulatory system. These SS-resistant cells …
Integrated cancer tissue engineering models for precision medicine
Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …
highly organized and interconnected organ systems. Tumor cells reside in complex …
Progression-mediated changes in mitochondrial morphology promotes adaptation to hypoxic peritoneal conditions in serous ovarian cancer
Ovarian cancer is the deadliest gynecological cancer in women, with a survival rate of less
than 30% when the cancer has spread throughout the peritoneal cavity. Aggregation of …
than 30% when the cancer has spread throughout the peritoneal cavity. Aggregation of …
Fluid shear stress stimulates breast cancer cells to display invasive and chemoresistant phenotypes while upregulating PLAU in a 3D bioreactor
Breast cancer cells experience a range of shear stresses in the tumor microenvironment
(TME). However most current in vitro three‐dimensional (3D) models fail to systematically …
(TME). However most current in vitro three‐dimensional (3D) models fail to systematically …
[HTML][HTML] A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: The best micropillar geometry?
M Rahmanian, OS Hematabad, E Askari… - Journal of Advanced …, 2023 - Elsevier
Introduction The information derived from the number and characteristics of circulating tumor
cells (CTCs), is crucial to ensure appropriate cancer treatment monitoring. Currently, diverse …
cells (CTCs), is crucial to ensure appropriate cancer treatment monitoring. Currently, diverse …
The role of intra-tumoral heterogeneity and its clinical relevance in epithelial ovarian cancer recurrence and metastasis
CM Roberts, C Cardenas, R Tedja - Cancers, 2019 - mdpi.com
Epithelial ovarian cancer is the deadliest gynecologic cancer, due in large part to recurrent
tumors. Recurrences tend to have metastasized, mainly in the peritoneal cavity and …
tumors. Recurrences tend to have metastasized, mainly in the peritoneal cavity and …
Mechanics and actomyosin-dependent survival/chemoresistance of suspended tumor cells in shear flow
Tumor cells disseminate to distant organs mainly through blood circulation in which they
experience considerable levels of fluid shear stress. However, the effects of hemodynamic …
experience considerable levels of fluid shear stress. However, the effects of hemodynamic …