Bright and early: Inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function
CS Adamson, MM Nevels - Viruses, 2020 - mdpi.com
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …
Phosphorylation events during viral infections provide potential therapeutic targets
JA Keating, R Striker - Reviews in medical virology, 2012 - Wiley Online Library
For many medically relevant viruses, there is now considerable evidence that both viral and
cellular kinases play important roles in viral infection. Ultimately, these kinases, and the …
cellular kinases play important roles in viral infection. Ultimately, these kinases, and the …
The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by interfering with the viral Immediate Early-2 (IE2) protein transactivating activity.
A Luganini, B Mercorelli, L Messa, G Palù, G Gribaudo… - Antiviral Research, 2019 - Elsevier
The identification and validation of new small molecules able to inhibit the replication of
human cytomegalovirus (HCMV) remains a priority to develop alternatives to the currently …
human cytomegalovirus (HCMV) remains a priority to develop alternatives to the currently …
Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly
The endoplasmic reticulum (ER) chaperone BiP/GRP78 regulates ER function and the
unfolded protein response (UPR). Human cytomegalovirus infection of human fibroblasts …
unfolded protein response (UPR). Human cytomegalovirus infection of human fibroblasts …
Functional roles of the human cytomegalovirus essential IE86 protein
MF Stinski, DT Petrik - Human cytomegalovirus, 2008 - Springer
The IE86 protein of human cytomegalovirus (HCMV) is unique among viral and cellular
proteins because it negatively autoregulates its own expression, activates the viral early and …
proteins because it negatively autoregulates its own expression, activates the viral early and …
[HTML][HTML] Immediate–early viral gene regulation and function
MF Stinski, JL Meier - Human herpesviruses: biology, therapy, and …, 2007 - ncbi.nlm.nih.gov
Betaherpesviruses such as human cytomegalovirus (HCMV), human herpesvirus-6A and 6B
(HHV-6), and human herpesvirus-7 (HHV-7) replicate more slowly than alphaherpesviruses …
(HHV-6), and human herpesvirus-7 (HHV-7) replicate more slowly than alphaherpesviruses …
Major immediate-early enhancer and its gene products
JL Meier, MF Stinski - Cytomegaloviruses: from molecular …, 2013 - iro.uiowa.edu
CMV major immediate-early (MIE) gene expression activates the viral replicative cycle in
both acute and reactivation infections and is greatly restricted in latent infection. Specific …
both acute and reactivation infections and is greatly restricted in latent infection. Specific …
Drug repurposing approach identifies inhibitors of the prototypic viral transcription factor IE2 that block human cytomegalovirus replication
B Mercorelli, A Luganini, G Nannetti, O Tabarrini… - Cell chemical …, 2016 - cell.com
New targets for antiviral strategies are needed against human cytomegalovirus (HCMV), a
major human pathogen. A cell-based screen aimed at finding inhibitors of the viral …
major human pathogen. A cell-based screen aimed at finding inhibitors of the viral …
Early inhibitors of human cytomegalovirus: state-of-art and therapeutic perspectives
B Mercorelli, D Lembo, G Palù, A Loregian - Pharmacology & therapeutics, 2011 - Elsevier
Human cytomegalovirus (HCMV) infection is associated with severe morbidity and mortality
in immunocompromised individuals, mainly transplant recipients and AIDS patients, and is …
in immunocompromised individuals, mainly transplant recipients and AIDS patients, and is …
[HTML][HTML] Betaherpes viral genes and their functions
ES Mocarski Jr - Human herpesviruses: biology, therapy, and …, 2007 - ncbi.nlm.nih.gov
Despite biological divergence, human cytomegalovirus (HCMV, HHV-5), on the one hand,
and the three human roseolaviruses (HHV-6A, HHV-6B, HHV-7), on the other hand, share …
and the three human roseolaviruses (HHV-6A, HHV-6B, HHV-7), on the other hand, share …