Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …

In multicellular organisms, epithelial cells are key elements of tissue organization. In
developing epithelial tissues, cellular proliferation and differentiation are under the tight …

Multipolar spindles are very rare in normal tissues, but they are much more prevalent in
many tumors, which might be induced by the mechanical confinements from overcrowding …

The direction in which a cell divides is set by the orientation of its mitotic spindle and is
important for determining cell fate, controlling tissue shape, and maintaining tissue …

Proper orientation of the mitotic spindle plays a crucial role in embryos, during tissue
development, and in adults, where it functions to dissipate mechanical stress to maintain …

The precise regulation of microtubule dynamics over time and space in dividing cells is
critical for several mitotic mechanisms that ultimately enable cell proliferation, tissue …

To segregate chromosomes in mitosis, cells assemble a mitotic spindle, a molecular
machine with centrosomes at two opposing cell poles and chromosomes at the equator …

During cell division, the mitotic spindle moves dynamically through the cell to position the
chromosomes and determine the ultimate spatial position of the two daughter cells. These …

The fate of the two daughter cells is intimately connected to their positioning, which is in turn
regulated by cell junction remodelling and orientation of the mitotic spindle. How multiple …

The dynamic process of mitotic spindle assembly depends on multitudes of inter-dependent
interactions involving kinetochores (KTs), microtubules (MTs), spindle pole bodies (SPBs) …