Nanotechnology has grown from a scientific interest to a major industry with both commodity
and specialty nanomaterial exposure to global populations and ecosystems. Sub-micron …

The generation of prosthetic implant wear after total joint arthroplasty is recognized as the
major initiating event in development of periprosthetic osteolysis and aseptic loosening, the …

Periprosthetic osteolysis remains the leading complication of total hip arthroplasty, often
resulting in aseptic loosening of the implant, and a requirement for revision surgery. Wear …

Wear debris, of deferent sizes, shapes and quantities, generated in artificial hip and knees is
largely confined to the bone and joint interface. This debris interacts with periprosthetic …

Conventional materials technology has yielded clear improvements in regenerative
medicine. Ideally, however, a replacement material should mimic the living tissue …

Aseptic loosening subsequent to periprosthetic osteolysis is the leading cause for the
revision of arthroplasty failure. The biological response of macrophages to wear debris has …

Periprosthetic osteolysis is the most common longterm complication of a total joint
arthroplasty, often resulting in aseptic loosening of the implant, which occurs in up to 34% of …

Activation of myeloid cells by orthopedic particulate debris is a key event in the
pathogenesis of periprosthetic osteolysis and implant loosening after total joint replacement …

Recently, nanometre-sized UHMWPE particles generated from hip and knee replacements
have been identified in vitro and in vivo. UHMWPE particles in the 0.1–1.0 μm size range …

This paper first presents a brief overview about the mechanism of wear particle formation as
well as wear particle characteristics in metal-on-polyethylene and metal-on-metal artificial …