Liquid biopsy of methylation biomarkers in cell-free DNA

H Luo, W Wei, Z Ye, J Zheng, R Xu - Trends in molecular medicine, 2021 - cell.com
Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …

Towards precision medicine: advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy

C Zeng, EK Stroup, Z Zhang, BCH Chiu… - Cancer …, 2019 - Springer
Robust and clinically convenient biomarkers for cancer diagnosis, early detection, and
prognosis have great potential to improve patient survival and are the key to precision …

Tumor fractions deciphered from circulating cell-free DNA methylation for cancer early diagnosis

X Zhou, Z Cheng, M Dong, Q Liu, W Yang, M Liu… - Nature …, 2022 - nature.com
Tumor-derived circulating cell-free DNA (cfDNA) provides critical clues for cancer early
diagnosis, yet it often suffers from low sensitivity. Here, we present a cancer early diagnosis …

Cell‐free DNA as a biomarker of aging

YV Teo, M Capri, C Morsiani, G Pizza, AMC Faria… - Aging cell, 2019 - Wiley Online Library
Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is
known to originate mainly from apoptotic cells. Here, we provide the first in vivo evidence of …

Environmental DNA methylation of Lymnaea stagnalis varies with age and is hypermethylated compared to tissue DNA

B Zhao, PM van Bodegom… - Molecular Ecology …, 2023 - Wiley Online Library
Environmental DNA (eDNA) approaches contributing to species identifications are quickly
becoming the new norm in biomonitoring and ecosystem assessments. Yet, information …

Dismir: D eep learning-based noninvasive cancer detection by i ntegrating dna s equence and methylation information of i ndividual cell-free dna r eads

J Li, L Wei, X Zhang, W Zhang, H Wang… - Briefings in …, 2021 - academic.oup.com
Detecting cancer signals in cell-free DNA (cfDNA) high-throughput sequencing data is
emerging as a novel noninvasive cancer detection method. Due to the high cost of …

TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis

Z Li, H Wu - Genome biology, 2019 - Springer
In the analysis of high-throughput data from complex samples, cell composition is an
important factor that needs to be accounted for. Except for a limited number of tissues with …

Cell-free DNA methylation profiling analysis—technologies and bioinformatics

J Huang, L Wang - Cancers, 2019 - mdpi.com
Analysis of circulating nucleic acids in bodily fluids, referred to as “liquid biopsies”, is rapidly
gaining prominence. Studies have shown that cell-free DNA (cfDNA) has great potential in …

Critical review on where CRISPR meets molecular diagnostics

A Lau, C Ren, LP Lee - Progress in Biomedical Engineering, 2020 - iopscience.iop.org
Simple yet powerful clustered regularly-interspaced short palindromic repeats (CRISPR)
technology has led to the advent of numerous developments in life sciences, biotechnology …

Detection of cell types contributing to cancer from circulating, cell-free methylated DNA

ME Barefoot, N Loyfer, AJ Kiliti, AP McDeed IV… - Frontiers in …, 2021 - frontiersin.org
Detection of cellular changes in tissue biopsies has been the basis for cancer diagnostics.
However, tissue biopsies are invasive and limited by inaccuracies due to sampling …