Poor water solubility and low bioavailability of active pharmaceutical ingredients (APIs) are
major causes of friction in the pharmaceutical industry and represent a formidable hurdle for …

Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …

Since several decades, PEGylation is known to be the clinical standard to enhance
pharmacokinetics of biotherapeutics. In this study, we introduce polyglycerol (PG) of different …

Protein-based therapeutics have revolutionized the pharmaceutical industry and become
vital components in the development of future therapeutics. They offer several advantages …

Despite landmark advances in cancer treatments over the last 20 years, cancer remains the
second highest cause of death worldwide, much ascribed to intrinsic and acquired …

Genetic code expansion (GCE) enables directed incorporation of noncoded amino acids
(NCAAs) and unnatural amino acids (UNAAs) into the active core that confers dedicated …

Zwitterionic polymers have been found to be biocompatible alternatives to poly (ethylene
glycol)(PEG) for conjugation to proteins. This work reports the site-selective conjugation of …

Ensuring site-selectivity in covalent chemical modification of proteins is one of the major
challenges in chemical biology and related biomedical disciplines. Most current strategies …

Hyperpolarization of small peptides by parahydrogen-induced polarization (PHIP) to
increase the sensitivity of nuclear magnetic resonance (NMR) techniques is well …

Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix
metalloproteinase (MMP) family of proteins, whose members are key regulators of the …