Elevated impulsivity is a symptom shared by various psychiatric disorders such as
substance use disorder, bipolar disorder, and attention-deficit/hyperactivity disorder …

Dopamine plays a key role in the cellular and behavioral responses to drugs of abuse, but
the implication of metabotropic regulatory input to dopaminergic neurons on acute drug …

Non-medical use of prescription stimulants amongst college students is common, with
claims of cognitive and academic benefits. The mechanism, magnitude, and pervasiveness …

Amphetamine (AMP), methylphenidate (MPH), and atomoxetine (ATX) are approved
treatments for ADHD, and together with nicotine (NIC), represent pharmacological agents …

Abstract Rationale The rodent Continuous Performance Test (rCPT) is a novel rodent
paradigm to assess attention and impulsivity that resembles the human CPT. This task …

Abstract The 22q11. 2 deletion syndrome (22q11. 2DS) confers high risk of
neurodevelopmental disorders such as schizophrenia and attention-deficit hyperactivity …

Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder characterized by
inattention, aberrant impulsivity, and hyperactivity. Although the underlying pathophysiology …

Abstract Background The rodent Continuous Performance Test (rCPT) is an analogue of
human CPTs where mice have to discriminate between target and non-target stimuli. The …

Atypical attention orienting has been found to be impaired in many neuropsychological
disorders, but the underlying neural mechanism remains unclear. Attention can be oriented …

Rationale Attention is compromised in many psychiatric disorders, including attention-
deficit/hyperactivity disorder (ADHD). While dopamine and noradrenaline systems have …