Highlights•Intraperitoneal Shigella infection is often used but lacks physiological
relevance.•The zebrafish larvae model is best for imaging studies.•The streptomycin-Nlrc4 …

Shigella spp. are the causative agent of shigellosis (or bacillary dysentery), a diarrhoeal
disease characterized for the bacterial invasion of gut epithelial cells. Among the 4 species …

Background Bacterial pathogens cause substantial diarrhea morbidity and mortality among
children living in endemic settings, yet antimicrobial treatment is only recommended for …

Antimicrobial and multidrug resistance (MDR) pathogens are becoming one of the major
health threats among children. Integrated studies on the molecular epidemiology and …

Shigella is the leading global etiological agent of shigellosis, especially in poor and
underdeveloped or developing nations with insufficient sanitation such as Bangladesh …

Shigellosis remains a common gastrointestinal disease mostly in children< 5 years of age in
developing countries. Azithromycin (AZM), a macrolide, is currently the first-line treatment for …

Shigella dysenteriae has been recognized as the second most prevalent pathogen
associated with diarrhea that contains blood, contributing to 12.9% of reported cases, and it …

The increasing use of antibiotics in food animal production systems has contributed to the
emergence of antibiotic-resistant zoonotic bacteria that are transmissible to humans via the …

In this introductory article, we describe the rationale for the Enterics for Global Health
(EFGH) Shigella surveillance study, which is largely to optimize the design and …

The early 20th century was a time of groundbreaking scientific progress. One major advance
was the development of penicillin and other antibiotics that has prevented thousands, even …