Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
M Cargnello, PP Roux - Microbiology and molecular biology …, 2011 - Am Soc Microbiol
The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
Molecular mechanisms and potential functions of histone demethylases
SM Kooistra, K Helin - Nature reviews Molecular cell biology, 2012 - nature.com
Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …
nuclear processes. Histone methylation was originally believed to be an irreversible …
High-throughput discovery of novel developmental phenotypes
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting
from knockouts of these genes in mice have provided tremendous insight into gene function …
from knockouts of these genes in mice have provided tremendous insight into gene function …
Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm
Background Human pluripotent stem cells offer the best available model to study the
underlying cellular and molecular mechanisms of human embryonic lineage specification …
underlying cellular and molecular mechanisms of human embryonic lineage specification …
Histone lysine demethylases as targets for anticancer therapy
It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …
are required for maintaining chromatin structure and cell identity include genes that drive …
Regulation and function of the RSK family of protein kinases
The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related
serine/threonine kinases that regulate diverse cellular processes, including cell growth …
serine/threonine kinases that regulate diverse cellular processes, including cell growth …
UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
The removal of histone H3 lysine27 (H3K27) trimethylation mark is important for the robust
induction of many cell type-specific genes during differentiation. Here we show that UTX, a …
induction of many cell type-specific genes during differentiation. Here we show that UTX, a …
UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
To investigate the role of histone H3K27 demethylase UTX in embryonic stem (ES) cell
differentiation, we have generated UTX knockout (KO) and enzyme-dead knock-in male ES …
differentiation, we have generated UTX knockout (KO) and enzyme-dead knock-in male ES …
CARM1 and paraspeckles regulate pre-implantation mouse embryo development
A Hupalowska, A Jedrusik, M Zhu, MT Bedford… - Cell, 2018 - cell.com
Nuclear architecture has never been carefully examined during early mammalian
development at the stages leading to establishment of the embryonic and extra-embryonic …
development at the stages leading to establishment of the embryonic and extra-embryonic …
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
JJ Barrott, GM Cash, AP Smith… - Proceedings of the …, 2011 - National Acad Sciences
The Drosophila porcupine gene is required for secretion of wingless and other Wnt proteins,
and sporadic mutations in its unique human ortholog, PORCN, cause a pleiotropic X-linked …
and sporadic mutations in its unique human ortholog, PORCN, cause a pleiotropic X-linked …