Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Abstract Cardiac miRNAs (miR-1, miR133a, miR-208a/b, and miR-499) are abundantly
expressed in the myocardium. They play a central role in cardiogenesis, heart function and …

Cell-based therapies have the potential to revolutionize current treatments for diseases with
high prevalence and related economic and social burden. Unfortunately, clinical trials have …

Mesenchymal stem cells have been used for cardiovascular regenerative therapy for
decades. These cells have been established as one of the potential therapeutic agents …

Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a
significant pathophysiological process involved in almost all forms of heart diseases …

Myocardial infarction (MI) is the leading cause of morbidity and mortality in the world. The
infarcted heart displays typical cell death cascades characterized by a loss of cells and …

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous
processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein …

Myocardial fibrosis is the result of excessive fibrillar collagen synthesis and deposition
without reciprocally balanced degradation. It causes cardiac dysfunction, arrhythmias, and …

Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte
apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart …

Providing a conducive microenvironment is critical to increase survival of transplanted stem
cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac …