Retinoic acid signaling and neuronal differentiation

A Janesick, SC Wu, B Blumberg - Cellular and Molecular Life Sciences, 2015 - Springer
The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

Regulation of neurogenesis by calcium signaling

AB Toth, AK Shum, M Prakriya - Cell calcium, 2016 - Elsevier
Abstract Calcium (Ca 2+) signaling has essential roles in the development of the nervous
system from neural induction to the proliferation, migration, and differentiation of neural cells …

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

MM Pathak, JL Nourse, T Tran, J Hwe… - Proceedings of the …, 2014 - National Acad Sciences
Neural stem cells are multipotent cells with the ability to differentiate into neurons,
astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the …

Waves in neural media

PC Bressloff - Lecture notes on mathematical modelling in the life …, 2014 - Springer
This is a book on mathematical neuroscience, in which the unifying theme is wavelike
phenomena at multiple spatial and temporal scales. There are already several excellent …

Calcium handling precedes cardiac differentiation to initiate the first heartbeat

RCV Tyser, AMA Miranda, C Chen, SM Davidson… - Elife, 2016 - elifesciences.org
The mammalian heartbeat is thought to begin just prior to the linear heart tube stage of
development. How the initial contractions are established and the downstream …

Triazole fungicides exert neural differentiation alteration through H3K27me3 modifications: In vitro and in silico study

T Ku, X Tan, Y Liu, R Wang, L Fan, Z Ren… - Journal of Hazardous …, 2023 - Elsevier
Considering that humans are unavoidably exposed to triazole fungicides through the
esophagus, respiratory tract, and skin contact, revealing the developmental toxicity of …

Combination of common mtDNA variants results in mitochondrial dysfunction and a connective tissue dysregulation

PM Schaefer, L Scherer Alves… - Proceedings of the …, 2022 - National Acad Sciences
Mitochondrial dysfunction can be associated with a range of clinical manifestations. Here,
we report a family with a complex phenotype including combinations of connective tissue …

Neonatal oxytocin treatment ameliorates autistic-like behaviors and oxytocin deficiency in valproic acid-induced rat model of autism

YC Dai, HF Zhang, M Schön, TM Böckers… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) is characterized by impaired social communication and
repetitive/stereotyped behaviors. The neuropeptide oxytocin (OXT) plays a critical role in …

TUNAR lncRNA encodes a microprotein that regulates neural differentiation and neurite formation by modulating calcium dynamics

E Senís, M Esgleas, S Najas… - Frontiers in cell and …, 2021 - frontiersin.org
Long noncoding RNAs (lncRNAs) are regulatory molecules which have been traditionally
considered as “non-coding”. Strikingly, recent evidence has demonstrated that many non …

Biomechanical cues as master regulators of hematopoietic stem cell fate

H Li, Q Luo, W Shan, S Cai, R Tie, Y Xu, Y Lin… - Cellular and Molecular …, 2021 - Springer
Hematopoietic stem cells (HSCs) perceive both soluble signals and biomechanical inputs
from their microenvironment and cells themselves. Emerging as critical regulators of the …