Structure-based mechanism and inhibition of cholesteryl ester transfer protein

H Xue, M Zhang, J Liu, J Wang, G Ren - Current Atherosclerosis Reports, 2023 - Springer
Abstract Purpose of Review Cholesteryl ester transfer proteins (CETP) regulate plasma
cholesterol levels by transferring cholesteryl esters (CEs) among lipoproteins. Lipoprotein …

High-density lipoprotein (HDL) in allergy and skin diseases: focus on immunomodulating functions

A Trakaki, G Marsche - Biomedicines, 2020 - mdpi.com
From an evolutionary perspective, lipoproteins are not only lipid transporters, but they also
have important functions in many aspects of immunity. High-density lipoprotein (HDL) …

LoTToR: an algorithm for missing-wedge correction of the low-tilt tomographic 3D reconstruction of a single-molecule structure

X Zhai, D Lei, M Zhang, J Liu, H Wu, Y Yu, L Zhang… - Scientific reports, 2020 - nature.com
A single-molecule three-dimensional (3D) structure is essential for understanding the
thermal vibrations and dynamics as well as the conformational changes during the chemical …

Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas

L Sprankel, D Vizarraga, J Martín, S Manger… - Nature Structural & …, 2023 - nature.com
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired
human pneumonia, needs to extract lipids from the host environment for survival and …

The pleiotropic effects of high-density lipoproteins and apolipoprotein AI

SR Thomas, Y Zhang, KA Rye - Best Practice & Research Clinical …, 2023 - Elsevier
The high density lipoprotein (HDL) fraction of human plasma consists of multiple
subpopulations of spherical particles that are structurally uniform, but heterogeneous in …

Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS

LJ Lebrun, G Pallot, M Nguyen, A Tavernier… - International Journal of …, 2022 - mdpi.com
Bacterial lipopolysaccharides (LPS, endotoxins) are found in high amounts in the gut lumen.
LPS can cross the gut barrier and pass into the blood (endotoxemia), leading to low-grade …

Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington's Disease

KH Chang, ML Cheng, CJ Lo, CM Fan, YR Wu… - Cells, 2023 - mdpi.com
Alterations in lipid composition and disturbed lipoprotein metabolism are involved in the
pathomechanism of Huntington's disease (HD). Here, we measured 112 lipoprotein …

Identification of Key Genes and Pathways in Genotoxic Stress Induced Endothelial Dysfunction: Results of Whole Transcriptome Sequencing

M Sinitsky, A Sinitskaya, D Shishkova, A Tupikin… - Biomedicines, 2022 - mdpi.com
Atherosclerosis is a leading cause of cardiovascular morbidity and mortality worldwide.
Endothelial disfunction underlying the atherogenesis can be triggered by genotoxic stress in …

Single-molecule 3D imaging of human plasma intermediate-density lipoproteins reveals a polyhedral structure

D Lei, Y Yu, YL Kuang, J Liu, RM Krauss… - Biochimica et Biophysica …, 2019 - Elsevier
Abstract Intermediate-density lipoproteins (IDLs), the remnants of very-low-density
lipoproteins via lipolysis, are rich in cholesteryl ester and are associated with cardiovascular …

Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

S Kononov, I Azarova, E Klyosova, M Bykanova… - Genes, 2023 - mdpi.com
We have shown that lipid-associated loci discovered by genome-wide association studies
(GWAS) have pleiotropic effects on lipid metabolism, carotid intima-media thickness (CIMT) …