Introduction: The osteoporosis market reached a value of more than $11 billion in 2015.
Current treatments remain mostly antiresorptive and comprise of bisphosphonates, the anti …

Cathepsin K (CTSK) was thought to be a collagenase, specifically expressed by osteoclasts,
and played an important role in bone resorption. However, more and more research found …

Purpose The aims of the present study were to discuss the demographic distribution and
clinical characteristics of patients with pycnodysostosis (PYCD) and the onset of …

Purpose Pycnodysostosis (PYCD), an autosomal recessive syndrome, is characterized by
an imbalance in bone remodeling that produces various clinical and radiographic …

Objective There is a lack of knowledge regarding pycnodysostosis (PYCD), which is
commonly misdiagnosed as other, similar malformations. This study aims to report a patient …

Pycnodysostosis is a rare autosomal recessive condition caused by the mutation of CTSK
gene. CTSK regulates the activity of Cathepsin K which is responsible for osteoclast …

Introduction: Pycnodysostosis is a rare autosomal recessive syndrome that provides the
abnormal bone metabolism that increases the susceptibility of patients to develop …

Conclusion: This case report presents the treatment history of this patient. With a longitudinal
observation period of greater than 20 years, the results of this case demonstrate the …

Склеротические остеодисплазии группа относительно редко встречающихся
заболеваний, общим признаком которых является диффузное или очаговое …

Pycnodysostosis is an autosomal recessive, rare genetic osteosclerotic disorder that caused
by mutation in gene coding for Cathepsin K. The bones in pycnodysostosis are abnormally …