Big data with cognitive computing: A review for the future

S Gupta, AK Kar, A Baabdullah… - International Journal of …, 2018 - Elsevier
Abstract Analysis of data by humans can be a time-consuming activity and thus use of
sophisticated cognitive systems can be utilized to crunch this enormous amount of data …

Analyzing protein–protein interaction networks

GCKW Koh, P Porras, B Aranda… - Journal of proteome …, 2012 - ACS Publications
The advent of the “omics” era in biology research has brought new challenges and requires
the development of novel strategies to answer previously intractable questions. Molecular …

[HTML][HTML] Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses

R Wang, CR Simoneau, J Kulsuptrakul, M Bouhaddou… - Cell, 2021 - cell.com
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …

Shifting the limits in wheat research and breeding using a fully annotated reference genome

International Wheat Genome Sequencing Consortium … - Science, 2018 - science.org
INTRODUCTION Wheat (Triticum aestivum L.) is the most widely cultivated crop on Earth,
contributing about a fifth of the total calories consumed by humans. Consequently, wheat …

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

K Kiryluk, E Sanchez-Rodriguez, XJ Zhou, F Zanoni… - Nature …, 2023 - nature.com
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …

[HTML][HTML] Integrated proteogenomic characterization of clear cell renal cell carcinoma

DJ Clark, SM Dhanasekaran, F Petralia, J Pan, X Song… - Cell, 2019 - cell.com
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma
(ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic …

Microbial network disturbances in relapsing refractory Crohn's disease

B Yilmaz, P Juillerat, O Øyås, C Ramon, FD Bravo… - Nature medicine, 2019 - nature.com
Inflammatory bowel diseases (IBD) can be broadly divided into Crohn's disease (CD) and
ulcerative colitis (UC) from their clinical phenotypes. Over 150 host susceptibility genes have …

[HTML][HTML] Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis

CL Wu, A Dicks, N Steward, R Tang, DB Katz… - Nature …, 2021 - nature.com
The therapeutic application of human induced pluripotent stem cells (hiPSCs) for cartilage
regeneration is largely hindered by the low yield of chondrocytes accompanied by …

Biological network exploration with Cytoscape 3

G Su, JH Morris, B Demchak… - Current protocols in …, 2014 - Wiley Online Library
Cytoscape is one of the most popular open‐source software tools for the visual exploration
of biomedical networks composed of protein, gene, and other types of interactions. It offers …

[HTML][HTML] clusterMaker: a multi-algorithm clustering plugin for Cytoscape

JH Morris, L Apeltsin, AM Newman, J Baumbach… - BMC …, 2011 - Springer
Background In the post-genomic era, the rapid increase in high-throughput data calls for
computational tools capable of integrating data of diverse types and facilitating recognition …