Preventing and treating anthracycline cardiotoxicity: new insights
Anthracyclines are the cornerstone of many chemotherapy regimens for a variety of cancers.
Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite …
Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite …
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …
forces are converted into chemical signals at the cell surface. However, mechanical forces …
Structure of the native myosin filament in the relaxed cardiac sarcomere
The thick filament is a key component of sarcomeres, the basic units of striated muscle.
Alterations in thick filament proteins are associated with familial hypertrophic …
Alterations in thick filament proteins are associated with familial hypertrophic …
Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin
MR Zile, CF Baicu, J S. Ikonomidis, RE Stroud… - Circulation, 2015 - Am Heart Assoc
Background—The purpose of this study was to determine whether patients with heart failure
and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness …
and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness …
Cryo-EM structure of the human cardiac myosin filament
Pumping of the heart is powered by filaments of the motor protein myosin that pull on actin
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …
Truncations of titin causing dilated cardiomyopathy
DS Herman, L Lam, MRG Taylor, L Wang… - … England Journal of …, 2012 - Mass Medical Soc
Background Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …
Performance of a shock isolator inspired by skeletal muscles
Nonlinear vibration isolators with low dynamic stiffness have advantages compared to linear
isolators, but they also have limitations in terms of the maximum allowable displacement …
isolators, but they also have limitations in terms of the maximum allowable displacement …
Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development
Background: The genetic basis of left ventricular (LV) image-derived phenotypes, which play
a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases …
a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases …
Mechanotransduction in cardiac hypertrophy and failure
RC Lyon, F Zanella, JH Omens, F Sheikh - Circulation research, 2015 - Am Heart Assoc
Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load
through a process known as mechanotransduction. In the heart, this process involves the …
through a process known as mechanotransduction. In the heart, this process involves the …
Dilated cardiomyopathy
JL Jefferies, JA Towbin - The Lancet, 2010 - thelancet.com
Dilated cardiomyopathy is characterised by left ventricular dilation that is associated with
systolic dysfunction. Diastolic dysfunction and impaired right ventricular function can …
systolic dysfunction. Diastolic dysfunction and impaired right ventricular function can …