Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its major
pathological hallmarks, neurofibrillary tangles (NFT), and amyloid-β plaques can result from …

Pheochromocytomas (PHEOs) are rare neuroendocrine tumors that arise from the
chromaffin cells of the adrenal glands. Paragangliomas (PGLs), the extra-adrenal …

Background Endometrial cancer is one of the most common gynecological cancers, which is
frequently preceded by atypical endometrial hyperplasia, a premalignant lesion. Metformin …

The four platelet-derived growth factor (PDGF) ligands and PDGF receptors (PDGFRs), α
and β (PDGFRA, PDGFRB), are essential proteins that are expressed during embryonic and …

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis.
Defects in this pathway in human cancer syndromes such as Cowden's disease and Multiple …

Despite the achieved progress in developing efficient MDM2-p53 protein-protein interaction
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors
originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic …

ABSTRACT Objective: Pheochromocytomas and paragangliomas (PPGLs) are
neuroendocrine tumors derived from adrenal or extra-adrenal locations, respectively. Upon …

Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that
exhibits low response rates to systemic therapy and poor patient outcomes. Multiple studies …

Metastatic pheochromocytomas and paragangliomas are rare, highly vascular tumors that
spread primarily to the lymph nodes, skeletal tissue, lungs, and liver. Tumor morbidity is …