The Factor H protein family: The switchers of the complement alternative pathway
L Lucientes‐Continente… - Immunological …, 2023 - Wiley Online Library
The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …
[HTML][HTML] The emerging role of complement proteins as a target for therapy of IgA nephropathy
DV Rizk, N Maillard, BA Julian, B Knoppova… - Frontiers in …, 2019 - frontiersin.org
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …
The role of complement in IgA nephropathy
A Tortajada, E Gutierrez, MC Pickering, MP Terente… - Molecular …, 2019 - Elsevier
IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …
[HTML][HTML] The contribution of complement to the pathogenesis of IgA nephropathy: are complement-targeted therapies moving from rare disorders to more common …
F Poppelaars, B Faria, W Schwaeble… - Journal of clinical …, 2021 - mdpi.com
Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney
failure for which there is no disease-specific treatment. However, this could change, since …
failure for which there is no disease-specific treatment. However, this could change, since …
[HTML][HTML] Regulation of regulators: Role of the complement factor H-related proteins
M Cserhalmi, A Papp, B Brandus, B Uzonyi… - Seminars in …, 2019 - Elsevier
The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …
innate immunity, may cause damage to the host and result in various inflammatory …
[HTML][HTML] Complement-mediated kidney diseases
F Poppelaars, JM Thurman - Molecular Immunology, 2020 - Elsevier
It has long been known that the complement cascade is activated in various forms of
glomerulonephritis. In many of these diseases, immune-complexes deposit in the glomeruli …
glomerulonephritis. In many of these diseases, immune-complexes deposit in the glomeruli …
The role of complement in kidney disease
V Petr, JM Thurman - Nature Reviews Nephrology, 2023 - nature.com
The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …
arm of the innate immune system. Once activated, the complement system rapidly generates …
[HTML][HTML] The role of immune modulation in pathogenesis of IgA nephropathy
S Chang, XK Li - Frontiers in Medicine, 2020 - frontiersin.org
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, with
diverse clinical manifestations characterized by recurrent gross hematuria or microscopic …
diverse clinical manifestations characterized by recurrent gross hematuria or microscopic …
CFHR gene variations provide insights in the pathogenesis of the kidney diseases atypical hemolytic uremic syndrome and C3 glomerulopathy
PF Zipfel, T Wiech, ED Stea… - Journal of the American …, 2020 - journals.lww.com
Sequence and copy number variations in the human CFHR–Factor H gene cluster
comprising the complement genes CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, and Factor H …
comprising the complement genes CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, and Factor H …