Adoptive T cell therapy (ACT) refers to the therapeutic use of T cells. T cells genetically
engineered to express chimeric antigen receptors (CAR) constitute the most clinically …

Despite acting as a barrier for the organs they encase, epithelial cells turn over at some of
the fastest rates in the body. However, epithelial cell division must be tightly linked to cell …

Semaphorins constitute a large family of membrane-bound and secreted proteins that
provide guidance cues for axon pathfinding and cell migration. Although initially discovered …

Abstract miR-543 has been implicated as having a critical role in the development of breast
cancer, endometrial cancer and hepatocellular carcinoma. However, the exact clinical …

Objective: Demonstrate intratumoral genetic heterogeneity in rectal cancer. Background:
Several clinical management decisions in rectal cancer may be influenced by pretreatment …

AXL is a tyrosine kinase receptor activated by GAS6 and regulates cancer cell proliferation
migration and angiogenesis. We studied AXL as new therapeutic target in colorectal cancer …

Purpose: Intratumoral genetic heterogeneity (ITGH) is a common feature of solid tumors.
However, little is known about the effect of neoadjuvant chemoradiation (nCRT) in ITGH of …

Background Gallbladder carcinoma (GBC) is one of the most aggressive and lethal tumors,
with extremely high metastatic activity and poor prognosis. Previously we have studied …

Amino acid transporters are abundant amongst the solute carrier family and have an
important role in facilitating the transfer of amino acids across cell membranes. Because of …

Although cancer has historically been regarded as a cell proliferation disorder, it has
recently been considered a metabolic disease. The first discovery of metabolic alterations in …