Inflammasome activation at the crux of severe COVID-19
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
COVID-19 vaccines: The status and perspectives in delivery points of view
Due to the high prevalence and long incubation periods often without symptoms, the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …
A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …
Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence
S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …
Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases
Abstract Since coronavirus disease-2019 (COVID-19) outbreak in January 2020, several
pieces of evidence suggested an association between the spectrum of Guillain–Barré …
pieces of evidence suggested an association between the spectrum of Guillain–Barré …
COVID‐19‐associated mucormycosis: an updated systematic review of literature
In its wake, the COVID‐19 pandemic has ushered in a surge in the number of cases of
mucormycosis. Most cases are temporally linked to COVID‐19; hence, the entity is described …
mucormycosis. Most cases are temporally linked to COVID‐19; hence, the entity is described …
The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu… - Signal transduction and …, 2021 - nature.com
Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
FS Oladunni, JG Park, PA Pino, O Gonzalez… - Nature …, 2020 - nature.com
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease
would benefit from validated small animal models. Here, we show that transgenic mice …
would benefit from validated small animal models. Here, we show that transgenic mice …