The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are
storage forms for messenger molecules that transmit signals across the cell membrane and …

Pertussis toxin (PTX) has been widely used as a reagent to characterize the involvement of
heterotrimeric G-proteins in signalling. This toxin catalyses the ADP-ribosylation of specific G …

The hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) by phospholipase C yields
the second messengers inositol 1, 4, 5-trisphosphate (InsP3) and 1, 2-diacylglycerol. This …

Heterotrimeric guanine nucleotide-binding proteins (G proteins) are integral to the signal
transduction pathways that mediate the cell's response to many hormones …

Abbreviations: Ptdlns-PLC, phosphoinositide specific phospholipase C; Ptdlns,
phosphatidylinositol; Ptdlns (4) P, phosphatidylinositol 4-phosphate; Ptdlns (4, 5) P 2 …

Shamshad Cockcroft glycerol Is the activator of protein kmase C (Ref 1) Thus, cellular
responses (eg contracnon, secretion or cell growth) can possibly be explamed on the basis …

The phospholipase C (PLC) isozymes catalyze conversion of phosphatidylinositol 4, 5-
bisphosphate (PtdIns (4, 5) P2) into the Ca2+-mobilizing second messenger inositol 1, 4, 5 …

Membranes prepared from [3 H] inositol-labeled turkey erythrocytes express a
phospholipase C that is markedly stimulated by stable analogs of GTP (Harden, TK …

Exposure of a nontransformed, continuous line of epithelial cells derived from rat liver (WB
cells) to epidermal growth factor, angiotensin II,[Arg8] vasopressin, and epinephrine resulted …

Exposure of A431 human epidermoid carcinoma cells to epidermal growth factor (EGF),
bradykinin, and histamine resulted in a time-and concentration-dependent accumulation of …