The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Iron-sulfur (Fe-S) clusters are ubiquitous cofactors composed of iron and inorganic sulfur.
They are required for the function of proteins involved in a wide range of activities, including …

Abstract Iron–sulfur (Fe/S) clusters are essential protein cofactors crucial for many cellular
functions including DNA maintenance, protein translation, and energy conversion. De novo …

Iron–sulfur (Fe/S) clusters belong to the most ancient protein cofactors in life, and fulfill
functions in electron transport, enzyme catalysis, homeostatic regulation, and sulfur …