Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment
GM Khandaker, L Cousins, J Deakin… - The Lancet …, 2015 - thelancet.com
Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …
Excess early mortality in schizophrenia
TM Laursen, M Nordentoft… - Annual review of clinical …, 2014 - annualreviews.org
Schizophrenia is often referred to as one of the most severe mental disorders, primarily
because of the very high mortality rates of those with the disorder. This article reviews the …
because of the very high mortality rates of those with the disorder. This article reviews the …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with human complex traits. However, the genes or functional DNA elements …
associated with human complex traits. However, the genes or functional DNA elements …
[HTML][HTML] Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian …
Background Schizophrenia, bipolar disorder and depression are associated with
inflammation. However, it is unclear whether associations of immunological proteins/traits …
inflammation. However, it is unclear whether associations of immunological proteins/traits …
Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: a cross-sectional study
Y Shen, J Xu, Z Li, Y Huang, Y Yuan, J Wang… - Schizophrenia …, 2018 - Elsevier
With the advent of sequencing technology, characterization of schizophrenia with underlying
probing of gut microbiome can provide abundant clues for diagnosis and prognosis of …
probing of gut microbiome can provide abundant clues for diagnosis and prognosis of …
[HTML][HTML] Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
M Fiorentino, A Sapone, S Senger, SS Camhi… - Molecular autism, 2016 - Springer
Background Autism spectrum disorders (ASD) are complex conditions whose pathogenesis
may be attributed to gene–environment interactions. There are no definitive mechanisms …
may be attributed to gene–environment interactions. There are no definitive mechanisms …
Celiac disease and non-celiac gluten sensitivity
Celiac disease is a multisystem immune based disorder that is triggered by the ingestion of
gluten in genetically susceptible individuals. The prevalence of celiac disease has risen in …
gluten in genetically susceptible individuals. The prevalence of celiac disease has risen in …
[HTML][HTML] Therapeutic potential of TAAR1 agonists in schizophrenia: evidence from preclinical models and clinical studies
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
Common variants conferring risk of schizophrenia
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …