This retrospective traces the hypothesis of ion channels from an early statement in a 1970
essay in this journal (Hille, B., 1970, Prog. Biophys. Mol. Biol. 21, 1–32) to its realization …

Kinetics of NMDA receptor (NMDAR) ion channel opening and closing contribute to their
unique role in synaptic signaling. Agonist binding generates free energy to open a canonical …

The liquid-to-vapor transition can occur under unexpected conditions in nanopores, opening
the door to fundamental questions and new technologies. The physics of boiling in …

Ion currents through potassium channels are gated. Constriction of the ion conduction
pathway at the inner helix bundle, the textbook gate of Kir potassium channels, has been …

A critical part of ion channel function is the ability to open and close in response to stimuli
and thus conduct ions in a regulated fashion. While x-ray diffraction studies of ion channels …

ABSTRACT A critical part of ion channel function is the ability to open and close in response
to stimuli, and thus conduct ions in a regulated fashion. While X-ray diffraction studies of ion …

The opening and closing kinetics of NMDA receptors (NMDARs) contribute to their unique
role in synaptic computation. NMDARs are heterotetramers composed of the obligate GluN1 …

Keywords: calyx afferent terminal; phase-locking; potassium ion accumulation; ribbon-type
synapses; semicircular canals; synaptic cleft; vestibular hair cells Holding the hair cell and …

Inwardly rectifying potassium (Kir) channels allow K+ flow more easily into than out of the
cell due to voltage-dependent block by intracellular Mg2+ and polyamines. Kir channel …

The Mechanism and Structural Basis of Conduction in an Inward Rectifier Potassium Ion
Channel Page 1 The Mechanism and Structural Basis of Conduction in an Inward Rectifier …