Neural control of breathing and CO2 homeostasis
PG Guyenet, DA Bayliss - Neuron, 2015 - cell.com
Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …
respiratory chemoreception). These mechanisms are reviewed and their significance is …
[HTML][HTML] Regulation of breathing and autonomic outflows by chemoreceptors
PG Guyenet - Comprehensive Physiology, 2014 - ncbi.nlm.nih.gov
Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
Understanding the rhythm of breathing: so near, yet so far
JL Feldman, CA Del Negro… - Annual review of …, 2013 - annualreviews.org
Breathing is an essential behavior that presents a unique opportunity to understand how the
nervous system functions normally, how it balances inherent robustness with a highly …
nervous system functions normally, how it balances inherent robustness with a highly …
Neuromodulation by extracellular ATP and P2X receptors in the CNS
BS Khakh, RA North - Neuron, 2012 - cell.com
Extracellular adenosine 5′ triphosphate (ATP) is a widespread cell-to-cell signaling
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …
Purinergic signaling mediates neuroglial interactions to modulate sighs
LJ Severs, NE Bush, LA Quina… - Nature …, 2023 - nature.com
Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions,
and are an expression of sadness and relief. Sighs are periodically superimposed on …
and are an expression of sadness and relief. Sighs are periodically superimposed on …
Mechanisms of CO2/H+ sensitivity of astrocytes
E Turovsky, SM Theparambil, V Kasymov… - Journal of …, 2016 - Soc Neuroscience
Ventral regions of the medulla oblongata of the brainstem are populated by astrocytes
sensitive to physiological changes in PCO2/[H+]. These astrocytes respond to decreases in …
sensitive to physiological changes in PCO2/[H+]. These astrocytes respond to decreases in …
CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits
L Meigh, SA Greenhalgh, TL Rodgers, MJ Cann… - Elife, 2013 - elifesciences.org
Homeostatic regulation of the partial pressure of CO2 (PCO2) is vital for life. Sensing of pH
has been proposed as a sufficient proxy for determination of PCO2 and direct CO2-sensing …
has been proposed as a sufficient proxy for determination of PCO2 and direct CO2-sensing …
Proton detection and breathing regulation by the retrotrapezoid nucleus
PG Guyenet, DA Bayliss, RL Stornetta… - The Journal of …, 2016 - Wiley Online Library
We discuss recent evidence which suggests that the principal central respiratory
chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons …
chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons …
Differential sensitivity of brainstem versus cortical astrocytes to changes in pH reveals functional regional specialization of astroglia
V Kasymov, O Larina, C Castaldo… - Journal of …, 2013 - Soc Neuroscience
Astrocytes might function as brain interoceptors capable of detecting different (chemo)
sensory modalities and transmitting sensory information to the relevant neural networks …
sensory modalities and transmitting sensory information to the relevant neural networks …
Brain H+/CO2 sensing and control by glial cells
AV Gourine, N Dale - Glia, 2022 - Wiley Online Library
Maintenance of constant brain pH is critically important to support the activity of individual
neurons, effective communication within the neuronal circuits, and, thus, efficient processing …
neurons, effective communication within the neuronal circuits, and, thus, efficient processing …