Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …

Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …

Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …

Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …

Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers
characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs …

To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Sample multiplexing facilitates scRNA-seq by reducing costs and identifying artifacts such
as cell doublets. However, universal and scalable sample barcoding strategies have not …

Metastases account for the great majority of cancer-associated deaths, yet this complex
process remains the least understood aspect of cancer biology. As the body of research …