The structural complexity of many natural products sets them apart from common synthetic
drugs, allowing them to access a biological target space that lies beyond the enzyme active …

Fluorine is a valuable probe for investigating the interactions of biological molecules
because of its favorable NMR characteristics, its small size, and its near total absence from …

The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules,
have mainly been explored in free solution. We report on the design, synthesis, and …

Solid-state nuclear magnetic resonance (ssNMR) spectroscopy enables the structural
characterization of a diverse array of biological assemblies that include amyloid fibrils, non …

Membrane proteins present a challenge for structural biology. In this article, we review some
of the recent developments that advance the application of NMR to membrane proteins, with …

The 3D structure and surface characteristics of proteins and peptides are crucial for
interactions with receptors or ligands and can be modified to some extent to modulate their …

There is some overlap in the biological activities of cell-penetrating peptides (CPPs) and
antimicrobial peptides (AMPs). We compared nine AMPs, seven CPPs, and a fusion peptide …

The membrane alignment of the amphiphilic α-helical model peptide MSI-103 (sequence
[KIAGKIA] 3-NH2) was examined by solid state 2H-NMR in different lipid systems by …

Despite extensive use of arginine‐rich cell‐penetrating peptides (CPPs)—including
octaarginine (R8)—as intracellular delivery vectors, mechanisms for their internalization are …

We report remarkably high, up to 100-fold, signal enhancements in 19F dynamic nuclear
polarization (DNP) magic angle spinning (MAS) spectra at 14.1 T on HIV-1 capsid protein …