Hereditary cancer syndromes constitute approximately 10% of all cancers. Cascade testing
involves testing of at-risk relatives to determine if they carry the familial pathogenic variant …

Abstract Knowledge of an underlying genetic predisposition to cancer allows the use of
personalised prognostic, preventive and therapeutic strategies for the patient and carries …

Singapore is a densely populated small island nation, with a multiethnic and multireligious
population. Cancer is the leading cause of death in Singapore. The population is well …

Background Cardiovascular diseases (CVDs) pose a significant global health challenge,
necessitating innovative approaches for primary prevention. Personalized prevention, based …

Introduction Identification of one's status as a BRCA1/2 pathogenic variant carrier often
marks the start of navigating challenging decisions related to cancer risk management and …

Background The uptake of risk-reducing salpingo-oophorectomy (RRSO) in Asian countries
is variable despite being the most effective option for ovarian cancer risk reduction in BRCA …

Individuals with rare genetic endocrine syndromes, such as von-Hippel Lindau, Multiple
Endocrine Neoplasia and mutations in the succinate dehydrogenase complex genes can …

Prophylactic surgery is usually a preventive surgical approach performed to significantly
reduce or eliminate the risk by total or partial removal of an organ with the risk of developing …