Immunometabolites in viral infections: Action mechanism and function

B Bouzari, UY Chugaeva, S Karampoor… - Journal of Medical …, 2024 - Wiley Online Library
The interplay between viral pathogens and host metabolism plays a pivotal role in
determining the outcome of viral infections. Upon viral detection, the metabolic landscape of …

Astrovirus replication is dependent on induction of double-membrane vesicles through a PI3K-dependent, LC3-independent pathway

T Bub, V Hargest, S Tan, M Smith… - Journal of …, 2023 - Am Soc Microbiol
Human astrovirus is a positive-sense, single-stranded RNA virus. Astrovirus infection causes
gastrointestinal symptoms and can lead to encephalitis in immunocompromised patients …

Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice

D Chen, J Wu, F Zhang, R Lyu, Q You… - EMBO Molecular …, 2024 - embopress.org
Innate immune cells have been acknowledged as trainable in recent years. While intestinal
tuft cells are recognized for their crucial roles in the host defense against intestinal …

[HTML][HTML] STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation

C Zhang, P Xu, Y Wang, X Chen, Y Pan, Z Ma… - … Pharmaceutica Sinica B, 2024 - Elsevier
Evading host immunity killing is a critical step for virus survival. Inhibiting viral immune
escape is crucial for the treatment of viral diseases. Serine/threonine kinase 39 (STK39) was …