Drug insight: selective agonists and antagonists of the glucocorticoid receptor

A McMaster, DW Ray - Nature Clinical Practice Endocrinology & …, 2008 - nature.com
Glucocorticoid hormones exert a wide spectrum of metabolic and immunological effects.
They function through the glucocorticoid receptor, a member of the nuclear receptor …

How do glucocorticoids cause hypertension: role of nitric oxide deficiency, oxidative stress, and eicosanoids

SLH Ong, JA Whitworth - Endocrinology and Metabolism …, 2011 - endo.theclinics.com
The discovery of the anti-inflammatory effects of corticosteroid hormones by Philip Hench
and colleagues in 1929 revolutionized the treatments of various inflammatory conditions …

Oleanolic acid prevents glucocorticoid‐induced hypertension in rats

SS Bachhav, SD Patil, MS Bhutada… - Phytotherapy …, 2011 - Wiley Online Library
The present study was designed to evaluate the antihypertensive activity of oleanolic acid
isolated from Viscum articulatum, Burm.(Loranthaceae) in glucocorticoid (dexamethasone) …

Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model

S Ahmad, BP Panda, K Kohli, M Fahim… - Pharmaceutical …, 2017 - Taylor & Francis
Context: The cardiotoxic effect of selective cyclo-oxygenase-2 inhibitors is well known. While
rofecoxib and valdecoxib have been withdrawn, celecoxib remains on the market. Folic acid …

Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain: Role of interleukin-6 and tumor necrosis factor-α

HSM Farghaly, AM Mahmoud… - European journal of …, 2016 - Elsevier
Dexmedetomidine (Dex) is a novel Alpha 2-adrenoceptor agonist. It decreases sympathetic
tone and attenuates the stress responses to anesthesia and surgery. People exposed to …

Folic acid attenuates vascular endothelial cell injury caused by hypoxia via the inhibition of ERK1/2/NOX4/ROS pathway

F Cheng, J Lan, W Xia, C Tu, B Chen, S Li… - Cell Biochemistry and …, 2016 - Springer
Coronary artery disease is a disease with high morbidity and mortality, in which vascular
endothelial dysfunction plays an important role. Hypoxia leads to the inflammation and …

[HTML][HTML] Oleanolic acid prevents increase in blood pressure and nephrotoxicity in nitric oxide dependent type of hypertension in rats

SS Bachhav, MS Bhutada, SP Patil… - Pharmacognosy …, 2015 - ncbi.nlm.nih.gov
Background: Recently, we have reported antihypertensive activity of oleanolic acid (OA) in
glucocorticoid-induced hypertension with restoration of nitric oxide (NO) level. However, the …

Mechanisms of dexamethasone-induced hypertension

SLH Ong, Y Zhang, JA Whitworth - Current Hypertension …, 2009 - ingentaconnect.com
Hypertension is a well-recognized complication of excess glucocorticoids, both naturally-
occurring and synthetic. Dexamethasone is a potent synthetic glucocorticoid, which has …

Folic acid administration prevents ouabain‐induced hyperlocomotion and alterations in oxidative stress markers in the rat brain

PS Brocardo, J Budni, E Pavesi, JL Franco… - Bipolar …, 2010 - Wiley Online Library
Brocardo PS, Budni J, Pavesi E, Franco JL, Uliano‐Silva M, Trevisan R, Terenzi MG, Dafre
AL, Rodrigues ALS. Folic acid administration prevents ouabain‐induced hyperlocomotion …

The effect of folic acid throughout pregnancy among pregnant women at high risk of pre-eclampsia: A randomized clinical trial

L Zheng, J Huang, H Kong, F Wang, Y Su, H Xin - Pregnancy hypertension, 2020 - Elsevier
Background Pre-eclampsia is a serious hypertension disease that occurs during pregnancy.
Folic acid (FA) supplementation has been reported to reduce pre-eclampsia risk in pregnant …