Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …

Abstract Cerebellins (Cbln1-4) are secreted adaptor proteins that connect presynaptic
neurexins (Nrxn1-3) to postsynaptic ligands (GluD1/2 for Cbln1-3 vs. DCC and Neogenin-1 …

At CA1→ subiculum synapses, alternatively spliced neurexin-1 (Nrxn1 SS4+) and neurexin-
3 (Nrxn3 SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively …

Rationale: Spinal cord injury (SCI) results in neural tissue damage. However, the limited
regenerative capacity of adult mammals' axons upon SCI leads to persistent neurological …

Structural plasticity, the ability of dendritic spines to change their volume in response to
synaptic stimulation, is an essential determinant of synaptic strength and long-term …

An organizational feature of neural circuits is the specificity of synaptic connections. A
striking example is the direction-selective (DS) circuit of the retina. There are multiple …

Synaptic structural plasticity, the expansion of dendritic spines in response to synaptic
stimulation, is essential for experience-dependent plasticity and is driven by branched actin …

Major depressive disorder (MDD) has been associated with deficits in working memory as
well as underlying gamma oscillation power. Consistent with this, overall reductions in …

Long-term potentiation (LTP) of synaptic transmission, possibly one of the most studied
cellular phenomena in neuroscience, refers to the long-lasting strengthening of a synaptic …

The pathophysiology underlying various manifestations of cerebral small vessel disease
(cSVD) remains obscure. Using cerebrospinal fluid proximity extension assays and co …