Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

STUDY QUESTION Can complete oocyte development be achieved from human ovarian
tissue containing primordial/unilaminar follicles and grown in vitro in a multi-step culture to …

Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

In most organisms, genome haploidization requires reciprocal DNA exchanges (crossovers)
between replicated parental homologs to form bivalent chromosomes. These are resolved to …

Removal and storage of ovarian cortical tissue is currently offered to young female cancer
patients undergoing potentially sterilizing chemotherapy and/or radiotherapy. For patients at …

STUDY QUESTION Can group culture with stage-specific anti-Müllerian hormone (AMH)
modulation support human follicular development and oocyte maturation in vitro …

Perfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl acid family of compounds.
Due to the presence of strong carbon–fluorine bonds, it is practically nonbiodegradable and …

Cell division in all eukaryotes depends on function of the spindle, a microtubule-based
structure that segregates chromosomes to generate daughter cells in mitosis or haploid …

STUDY HYPOTHESIS How does the ultrastructure of human oocytes matured in vitro
compare with oocytes collected from women after full hormonal stimulation? STUDY …