Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

The bone marrow microenvironment contains a heterogeneous population of stromal cells
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …

The myelodysplastic syndromes (MDS) share their origin in the hematopoietic stem cell but
have otherwise very heterogeneous biological and genetic characteristics. Clinical features …

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …

Several haematological malignancies, including multiple myeloma (MM) and acute myeloid
leukaemia (AML), have well-defined precursor states that precede the development of overt …

Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple
myeloma (MM) are age-related haematological malignancies with defined precursor states …

Research in the last few years has revealed a sophisticated interaction network between
multiple bone marrow cells that regulate different hematopoietic stem cell (HSC) properties …

Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important
effectors of anticancer immune response. These cells can survey and control tumor initiation …

Hematopoietic insufficiency is the hallmark of acute myeloid leukemia (AML) and
predisposes patients to life-threatening complications such as bleeding and infections …