Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The
specific T cells that mediate tumor rejection are unknown. T cells from human bladder …

Platinum-based anticancer drugs (PADs), mainly cisplatin, carboplatin, and oxaliplatin, are
widely used efficacious long-standing anticancer agents for treating several cancer types …

Immunotherapy aims to activate the immune system to fight cancer in a very specific and
targeted manner. Despite the success of different immunotherapeutic strategies, in particular …

Understanding mechanisms of late/acquired cancer immunotherapy resistance is critical to
improve outcomes; cellular immunotherapy trials offer a means to probe complex tumor …

Background There has been no report of prognostic signature based on immune-related
genes (IRGs). This study aimed to develop an IRG-based prognostic signature that could …

Background The TGF-β pathway plays critical roles in numerous malignancies.
Nevertheless, its potential role in prognosis prediction and regulating tumour …

The JAK-STAT signalling pathway regulates cellular processes like cell division, cell death
and immune regulation. Dysregulation has been identified in solid tumours and STAT3 …

Immune checkpoint molecules, such as PD-1/PD-L1, are reported to be closely associated
with suppression of antitumor immunity, and their inhibitors have been used to treat various …

RNA sequencing (RNA-seq) provides an efficient high-throughput technique to robustly
characterize the tumor immune microenvironment (TME). The increasing use of RNA-seq in …

Background Glioma is one of the highly fatal primary tumors in the central nervous system.
As a major component of tumor microenvironment (TME), immune cell has been proved to …