Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease

LCD Smyth, HC Murray, M Hill, E van Leeuwen… - Acta neuropathologica …, 2022 - Springer
Introduction Neutrophil accumulation is a well-established feature of Alzheimer's disease
(AD) and has been linked to cognitive impairment by modulating disease-relevant …

Characterisation of PDGF-BB: PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease

LCD Smyth, B Highet, D Jansson, J Wu… - Communications …, 2022 - nature.com
Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Aggregate-prone brain regions in Parkinson's disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility

JA Wiseman, HC Murray, RLMF Faull… - npj Parkinson's …, 2024 - nature.com
In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …

[HTML][HTML] N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease

FE Layburn, AYS Tan, NF Mehrabi, MA Curtis… - Neurobiology of …, 2022 - Elsevier
Huntington's disease (HD) is caused by a CAG repeat expansion mutation in the gene
encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming …

PSA-NCAM regulatory gene expression changes in the Alzheimer's disease entorhinal cortex revealed with multiplexed in situ hybridization

B Highet, JA Wiseman, H Mein… - Journal of …, 2023 - content.iospress.com
Background: Alzheimer's disease (AD) is the most common form of dementia and is
characterized by a substantial reduction of neuroplasticity. Our previous work demonstrated …

[HTML][HTML] Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex

AYS Tan, LJ Tippett, CP Turner, MEV Swanson… - Neurobiology of …, 2024 - Elsevier
Huntington's disease (HD) is a neurodegenerative disorder that severely affects the basal
ganglia and regions of the cerebral cortex. While astrocytosis and microgliosis both …

Covalently attaching hollow silica nanoparticles on a COC surface for the fabrication of a three-dimensional protein microarray

J Yan, C Zhao, Y Ma, W Yang - Biomacromolecules, 2022 - ACS Publications
Compared to traditional two-dimensional (2D) biochips, three-dimensional (3D) biochips
exhibit the advantages of higher probe density and detection sensitivity due to their …

[HTML][HTML] TMA-Mate: An open-source modular toolkit for constructing tissue microarrays of arbitrary layouts

N Pazaitis, A Kaiser - HardwareX, 2023 - Elsevier
Biomedical research and quality control procedures often demand a variety of microscopic
analysis of numerous formalin-fixed and paraffin-embedded (FFPE) tissue samples from …

Co-Expression of Nogo-A in dopaminergic neurons of the human substantia nigra pars compacta is reduced in Parkinson's disease

GC Eyer, S Di Santo, E Hewer, L Andereggen, S Seiler… - Cells, 2021 - mdpi.com
Parkinson's disease is mainly characterized by a progressive loss of dopaminergic neurons
in the substantia nigra pars compacta. Together with the small number, the high vulnerability …

Tumour infiltrating lymphocyte density differs by meningioma type and is associated with prognosis in atypical meningioma

CP Turner, J McLay, IF Hermans, J Correia, A Bok… - Pathology, 2022 - Elsevier
Tumour infiltrating lymphocyte (TIL) density is prognostically significant in various tumours,
but few studies have investigated its significance in meningioma. This study aimed to …