Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease
Introduction Neutrophil accumulation is a well-established feature of Alzheimer's disease
(AD) and has been linked to cognitive impairment by modulating disease-relevant …
(AD) and has been linked to cognitive impairment by modulating disease-relevant …
Characterisation of PDGF-BB: PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease
Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …
brain pericytes is critical to the development, maintenance and function of a healthy blood …
Aggregate-prone brain regions in Parkinson's disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility
JA Wiseman, HC Murray, RLMF Faull… - npj Parkinson's …, 2024 - nature.com
In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …
form a myriad of conformational and truncational variants. Most antibodies used to detect …
[HTML][HTML] N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease
FE Layburn, AYS Tan, NF Mehrabi, MA Curtis… - Neurobiology of …, 2022 - Elsevier
Huntington's disease (HD) is caused by a CAG repeat expansion mutation in the gene
encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming …
encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming …
PSA-NCAM regulatory gene expression changes in the Alzheimer's disease entorhinal cortex revealed with multiplexed in situ hybridization
B Highet, JA Wiseman, H Mein… - Journal of …, 2023 - content.iospress.com
Background: Alzheimer's disease (AD) is the most common form of dementia and is
characterized by a substantial reduction of neuroplasticity. Our previous work demonstrated …
characterized by a substantial reduction of neuroplasticity. Our previous work demonstrated …
[HTML][HTML] Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex
Huntington's disease (HD) is a neurodegenerative disorder that severely affects the basal
ganglia and regions of the cerebral cortex. While astrocytosis and microgliosis both …
ganglia and regions of the cerebral cortex. While astrocytosis and microgliosis both …
Covalently attaching hollow silica nanoparticles on a COC surface for the fabrication of a three-dimensional protein microarray
J Yan, C Zhao, Y Ma, W Yang - Biomacromolecules, 2022 - ACS Publications
Compared to traditional two-dimensional (2D) biochips, three-dimensional (3D) biochips
exhibit the advantages of higher probe density and detection sensitivity due to their …
exhibit the advantages of higher probe density and detection sensitivity due to their …
[HTML][HTML] TMA-Mate: An open-source modular toolkit for constructing tissue microarrays of arbitrary layouts
N Pazaitis, A Kaiser - HardwareX, 2023 - Elsevier
Biomedical research and quality control procedures often demand a variety of microscopic
analysis of numerous formalin-fixed and paraffin-embedded (FFPE) tissue samples from …
analysis of numerous formalin-fixed and paraffin-embedded (FFPE) tissue samples from …
Co-Expression of Nogo-A in dopaminergic neurons of the human substantia nigra pars compacta is reduced in Parkinson's disease
GC Eyer, S Di Santo, E Hewer, L Andereggen, S Seiler… - Cells, 2021 - mdpi.com
Parkinson's disease is mainly characterized by a progressive loss of dopaminergic neurons
in the substantia nigra pars compacta. Together with the small number, the high vulnerability …
in the substantia nigra pars compacta. Together with the small number, the high vulnerability …
Tumour infiltrating lymphocyte density differs by meningioma type and is associated with prognosis in atypical meningioma
Tumour infiltrating lymphocyte (TIL) density is prognostically significant in various tumours,
but few studies have investigated its significance in meningioma. This study aimed to …
but few studies have investigated its significance in meningioma. This study aimed to …