Exploiting the folate receptor α in oncology

M Scaranti, E Cojocaru, S Banerjee… - Nature reviews clinical …, 2020 - nature.com
Folate receptor α (FRα) came into focus as an anticancer target many decades after the
successful development of drugs targeting intracellular folate metabolism, such as …

Advances in lung cancer treatment using nanomedicines

A Sharma, D Shambhwani, S Pandey, J Singh… - ACS …, 2022 - ACS Publications
Carcinoma of the lungs is among the most menacing forms of malignancy and has a poor
prognosis, with a low overall survival rate due to delayed detection and ineffectiveness of …

Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

[HTML][HTML] Targeting folate receptor alpha for cancer treatment

A Cheung, HJ Bax, DH Josephs, KM Ilieva… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Promising targeted treatments and immunotherapy strategies in oncology and
advancements in our understanding of molecular pathways that underpin cancer …

CAR-T cell therapy in triple-negative breast cancer: Hunting the invisible devil

F Nasiri, M Kazemi, SMJ Mirarefin… - Frontiers in …, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is known as the most intricate and hard-to-treat
subtype of breast cancer. TNBC cells do not express the well-known estrogen receptor …

Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications

V Gubala, G Giovannini, F Kunc, MP Monopoli… - Cancer …, 2020 - Springer
Background Fluorescent silica nanoparticles have been extensively utilised in a broad
range of biological applications and are facilitated by their predictable, well-understood …

Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

HJ Bax, J Chauhan, C Stavraka, A Santaolalla… - British Journal of …, 2023 - nature.com
Background Survival rates for ovarian cancer remain poor, and monitoring and prediction of
therapeutic response may benefit from additional markers. Ovarian cancers frequently …

Folic acid-functionalized, condensed magnetic nanoparticles for targeted delivery of doxorubicin to tumor cancer cells overexpressing the folate receptor

A Angelopoulou, A Kolokithas-Ntoukas, C Fytas… - ACS …, 2019 - ACS Publications
This study concerns the development of folic acid (FA)-functionalized iron oxide condensed
colloidal magnetic clusters for a more selective delivery of doxorubicin (DOX) to tumor …

Cancer vaccines for triple-negative breast cancer: a systematic review

M Hosseini, S Seyedpour, B Khodaei, AH Loghman… - Vaccines, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is the subtype of breast cancer with the poorest
outcomes, and is associated with a high risk of relapse and metastasis. The treatment …

Anticancer nanotherapeutics in clinical trials: The work behind clinical translation of nanomedicine

A Parodi, EP Kolesova, MV Voronina… - International Journal of …, 2022 - mdpi.com
The ultimate goal of nanomedicine has always been the generation of translational
technologies that can ameliorate current therapies. Cancer disease represented the primary …