Blood-to-brain communication in aging and rejuvenation
Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer's disease (AD): a systematic review and meta-analysis
Findings from previous studies reporting the levels of serum brain-derived neurotrophic
factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive …
factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive …
β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice
Y Zhao, Q Zheng, Y Hong, Y Gao, J Hu, M Lang… - Nature …, 2023 - nature.com
Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Aging drives cognitive and regenerative impairments in the adult brain, increasing
susceptibility to neurodegenerative disorders in healthy individuals,,,. Experiments using …
susceptibility to neurodegenerative disorders in healthy individuals,,,. Experiments using …
Disease detection with molecular biomarkers: from chemistry of body fluids to nature-inspired chemical sensors
YY Broza, X Zhou, M Yuan, D Qu, Y Zheng… - Chemical …, 2019 - ACS Publications
This article aims to review nature-inspired chemical sensors for enabling fast, relatively
inexpensive, and minimally (or non-) invasive diagnostics and follow-up of the health …
inexpensive, and minimally (or non-) invasive diagnostics and follow-up of the health …
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease
ND Beckmann, WJ Lin, M Wang, AT Cohain… - Nature …, 2020 - nature.com
Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer's
disease (AD) remains elusive. To better characterize the complex nature of AD, we …
disease (AD) remains elusive. To better characterize the complex nature of AD, we …
[HTML][HTML] DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing
The ability to estimate the age of the donor from recovered biological material at a crime
scene can be of substantial value in forensic investigations. Aging can be complex and is …
scene can be of substantial value in forensic investigations. Aging can be complex and is …
Urinary proteome profiling for stratifying patients with familial Parkinson's disease
The prevalence of Parkinson's disease (PD) is increasing but the development of novel
treatment strategies and therapeutics altering the course of the disease would benefit from …
treatment strategies and therapeutics altering the course of the disease would benefit from …
[HTML][HTML] Brain endothelial cells are exquisite sensors of age-related circulatory cues
Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB),
protecting the brain from pathogens and restricting access of circulatory factors. Yet …
protecting the brain from pathogens and restricting access of circulatory factors. Yet …
The extended granin family: structure, function, and biomedical implications
A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …