Epilepsy is characterized by spontaneous recurrent seizures and comprises a diverse group
of syndromes with different etiologies. Epileptogenesis refers to the process whereby the …

The Aristaless‐related homeobox gene (ARX) is one of the most frequently mutated genes
in a spectrum of X‐chromosome phenotypes with intellectual disability (ID) as their cardinal …

Identifying the neuronal cell types that comprise the mammalian forebrain is a central
unsolved problem in neuroscience. Global gene expression profiles offer a potentially …

Summary T-brain gene-2 (Tbr2) is specifically expressed in the intermediate (basal)
progenitor cells (IPCs) of the developing cerebral cortex; however, its function in this …

LIM homeodomain transcription factors, Lmx1a and Lmx1b, are required for the
development of midbrain dopaminergic (mDA) neurons. Lmx1b is required for the …

Infantile spasms syndrome (ISS) is a catastrophic pediatric epilepsy with motor spasms,
persistent seizures, mental retardation, and in some cases, autism. One of its monogenic …

Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …

Background: ARX is a paired-type homeobox gene located on the X chromosome that
contains five exons with four polyalanine (PolyA) tracts, a homeodomain, and a conserved C …

The Arx transcription factor is expressed in the developing ventral telencephalon and
subsets of its derivatives. Mutation of human ARX ortholog causes neurological disorders …

Bioinspired by native nervous tracts, a spinal cord-mimicking model system that was
composed of multiple nanofibrous yarns (NYs) ensheathed in a nanofibrous tube was …