Photoaffinity labeling (PAL) using a chemical probe to covalently bind its target in response
to activation by light has become a frequently used tool in drug discovery for identifying new …

The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

Under tension: A set of genetically encoded unnatural amino acids can be used for
biocompatible site‐specific labeling of proteins with fluorogenic dyes. The new compounds …

The synthesis of 3-trifluoromethyl-3-phenyldiazirine (TPD) is reported in an overall yield of
60% based on 2, 2, 2-trifluoroacetophenone as starting material. TPD is rapidly photolyzed …

Bioorthogonal chemistry has enabled the selective labeling and detection of biomolecules in
living systems. Bioorthogonal smart probes, which become fluorescent or deliver imaging or …

Biomoleküle in ihrer natürlichen Umgebung zu erforschen, ist wegen der enormen
Komplexität zellulärer Systeme eine anspruchsvolle Aufgabe. In den letzten Jahren …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Fluorescent probes designed for activation by bioorthogonal chemistry have enabled the
visualization of biomolecules in living systems. Such activatable probes with near-infrared …

The structure of sialic acid on living cells can be modulated by metabolism of unnatural
biosynthetic precursors. Here we investigate the conversion of a panel of azide …

A recently developed proteomics strategy, designated tagging-via-substrate (TAS)
approach, is described for the detection and proteomic analysis of farnesylated proteins …