The disease severity and clinical outcomes of the SARS-CoV-2 variants of concern

L Lin, Y Liu, X Tang, D He - Frontiers in public health, 2021 - frontiersin.org
With the continuation of the pandemic, many severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) variants have appeared around the world. Owing to a possible risk of …

Biological properties of SARS-CoV-2 variants: Epidemiological impact and clinical consequences

R Hoteit, HM Yassine - Vaccines, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to
the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May …

Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals

A Brizzi, C Whittaker, LMS Servo, I Hawryluk… - Nature medicine, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant of
concern has spread rapidly across Brazil since late 2020, causing substantial infection and …

Severity of COVID-19 cases in the months of predominance of the Alpha and Delta variants

D Florensa, J Mateo, R Spaimoc, C Miret, S Godoy… - Scientific Reports, 2022 - nature.com
New SARS-CoV-2 may pose problems in controlling the COVID-19 pandemic for public
health. We aimed to assess and compare the symptoms and severity of cases due to the …

[HTML][HTML] SARS-CoV-2: emergence of new variants and effectiveness of vaccines

DD Singh, A Parveen, DK Yadav - Frontiers in cellular and infection …, 2021 - frontiersin.org
The advent of SARS-CoV-2 variants may cause resistance at the immunity level against
current vaccines. Some emergent new variants have increased transmissibility, infectivity …

Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies

IM Rouzine, G Rozhnova - Communications Medicine, 2023 - nature.com
Once the first SARS-CoV-2 vaccine became available, mass vaccination was the main pillar
of the public health response to the COVID-19 pandemic. It was very effective in reducing …

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B. 1 strain in human cells with low ACE2 expression

D Niemeyer, S Stenzel, T Veith, S Schroeder… - PLoS …, 2022 - journals.plos.org
Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible …

[HTML][HTML] Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent

DJ Pascall, E Vink, R Blacow, N Bulteel, A Campbell… - Journal of Infection, 2023 - Elsevier
Objectives To determine how the intrinsic severity of successively dominant SARS-CoV-2
variants changed over the course of the pandemic. Methods A retrospective cohort analysis …

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

KS Lee, TY Wong, BP Russ, AM Horspool, OA Miller… - Plos one, 2022 - journals.plos.org
The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC)
that have increased transmissibility, receptor binding affinity, and other properties that …

Assessing the impacts of COVID-19 vaccination programme's timing and speed on health benefits, cost-effectiveness, and relative affordability in 27 African countries

Y Liu, SR Procter, CAB Pearson, AM Montero… - BMC medicine, 2023 - Springer
Background The COVID-19 vaccine supply shortage in 2021 constrained roll-out efforts in
Africa while populations experienced waves of epidemics. As supply improves, a key …