With the aging of the population, the burden of Alzheimer's disease (AD) is rapidly
expanding. More than 5 million people in the US alone are affected with AD and this number …

The idea of reserve against brain damage stems from the repeated observation that there
does not appear to be a direct relationship between the degree of brain pathology or brain …

A model of the effects of aging on brain activity during cognitive performance is introduced.
The model is called HAROLD (hemispheric asymmetry reduction in older adults), and it …

Objective The purpose of this study was to review the relationship between education and
dementia. Methods A systematic literature review was conducted of all published studies …

A prospective analysis of risk factors for Alzheimer's disease was a major objective of the
Canadian Study of Health and Aging, a nationwide, population-based study. Of 6,434 …

Objective.—To determine if linguistic ability in early life is associated with cognitive function
and Alzheimer's disease in late life. Design.—Two measures of linguistic ability in early life …

BACKGROUND: Subjective cognitive impairment (SCI) in older persons without manifest
symptomatology is a common condition with a largely unclear prognosis. We hypothesized …

Objective: To investigate the risk of AD associated with a family history of dementia, female
gender, low levels of education, smoking, and head trauma. Background: These putative …

Illiterates represent a significant proportion of the world's population. Written language not
only plays a role in mediating cognition, but also extends our knowledge of the world. Two …

Background Depression symptoms may be associated with the development of Alzheimer
disease (AD). Objectives To evaluate the association between depression symptoms and …