The molecular mechanisms and signal transduction cascades evoked by the activation of
aryl hydrocarbon receptor (AhR) are becoming increasingly understandable. AhR is a ligand …

Primary central nervous system tumors are the most frequent solid tumors in children,
accounting for over 40% of all childhood brain tumor deaths, specifically high-grade …

Simple Summary tRF-27 has been identified as upregulated in both naïve trastuzumab-
resistant HER2-positive breast cancer cells and patient samples, positioning it as a potential …

Multiple signaling pathways facilitate the survival and drug resistance of malignant B-cells
by regulating their migration and adhesion to microenvironmental niches. NF-κB pathways …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end‑
stage renal disease, and is characterized by persistent proteinuria and decreased …

4-Quinolone derivatives undergo an unexpected ring expansion reaction with α-halo
esters/phosphonates/sulfones in the presence of a base, such as NaH, to produce novel …

The interplay between genetic alterations and metabolic dysregulation is increasingly
recognized as a pivotal axis in cancer pathogenesis. Both elements are mutually reinforcing …

Gene therapy is a focus of interest in both human and veterinary medicine, especially in
recent years due to the potential applications of CRISPR/Cas9 technology. Another …

Background Epigenetic changes that lead to long-term neuroadaptations following opioid
exposure are not well understood. We examined how histone demethylase JMJD3 in the …

Purpose: The purpose of this study was to investigate the antitumor effects of GSK-J4 on
retinoblastoma, as well as its related biological functions and molecular mechanisms …