Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO•
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …

Macrovascular disease is the number one killer in type 2 diabetes patients. The cluster of
risk factors in the insulin resistance syndrome (IRS) partly explains this notion. Insulin action …

Context: The interaction of advanced glycation end products, including N ε-(carboxymethyl)
lysine-protein adducts (CML) and S100A12 protein, with their cellular receptor (RAGE) is …

OBJECTIVE—After the demonstration that one-third of male patients with type 2 diabetes
have hypogonadotrophic hypogonadism, we have shown that patients with …

Aims/hypothesis In type 2 diabetes, in contrast to the well-documented endothelial
dysfunction, studies assessing vascular smooth muscle (VSM) function have yielded …

Erythropoietin (EPO) mediates a wide range of neuroprotective activities, including
amelioration of disease and neuroinflammation in rat models of EAE. However, optimum …

Nitric oxide (NO) is a physiologically important modulator of both vasomotor tone and
platelet aggregability. These effects of NO are predominantly mediated by cyclic guanosine …

Background Anaemia has been shown in previous studies to be a risk factor for
cardiovascular disease in diabetic patients with chronic kidney disorder. This study was …

Purpose: Antineoplastic drugs, such as cisplatin (CDDP), are severely neurotoxic, causing
disabling peripheral neuropathies with clinical signs known as chemotherapy-induced …

Hematological parameters including red blood cell (RBC) count, hematocrit (Hct), and
hemoglobin (Hgb) are independently associated with insulin resistance. The aim of this …