Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …

Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in
cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) …

Cells respond to their environment by sensing signals and translating them into changes in
gene expression. In recent years, synthetic networks have been designed in both …

The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL)
selectively induces apoptosis in a variety of cancer cells through the activation of death …

Standard treatment of locally advanced cervical cancer currently consists of concurrent
chemoradiation, leading to a 5-year disease-free survival of 66-79%, indicating that there is …

JMA Kuijlen, E. Bremer, JJA Mooij, WFA den Dunnen and W. Helfrich (2010)
Neuropathology and Applied Neurobiology36, 168–182 On TRAIL for malignant glioma …

Background: Tumour cell-selective activation of apoptosis by recombinant human TNF-
related apoptosis-inducing ligand (rhTRAIL) is enhanced through co-activation of p53 by …

The tumor necrosis factor (TNF) ligand family has nine ligands that show promiscuity in
binding multiple receptors. As different receptors transduce into diverse pathways, the study …

Purpose: To identify and characterize epigenetically regulated genes able to predict
sensitivity or resistance to currently tested chemotherapeutic agents in glioma therapy …

Current treatment modalities for pancreatic carcinoma afford only modest survival benefits.
TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising …