[HTML][HTML] Organoid and spheroid tumor models: techniques and applications

S Gunti, ATK Hoke, KP Vu, NR London Jr - Cancers, 2021 - mdpi.com
Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …

[HTML][HTML] Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

[HTML][HTML] Large-scale perfused tissues via synthetic 3D soft microfluidics

S Grebenyuk, AR Abdel Fattah, M Kumar… - Nature …, 2023 - nature.com
The vascularization of engineered tissues and organoids has remained a major unresolved
challenge in regenerative medicine. While multiple approaches have been developed to …

[HTML][HTML] AI-enabled organoids: construction, analysis, and application

L Bai, Y Wu, G Li, W Zhang, H Zhang, J Su - Bioactive Materials, 2024 - Elsevier
Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …

Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

[HTML][HTML] Promising applications of tumor spheroids and organoids for personalized medicine

Z Gilazieva, A Ponomarev, C Rutland, A Rizvanov… - Cancers, 2020 - mdpi.com
Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …

In vitro strategies to vascularize 3D physiologically relevant models

A Dellaquila, C Le Bao, D Letourneur… - Advanced …, 2021 - Wiley Online Library
Vascularization of 3D models represents a major challenge of tissue engineering and a key
prerequisite for their clinical and industrial application. The use of prevascularized models …

Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective

SN Rai, VK Chaturvedi, P Singh, BK Singh, MP Singh - 3 Biotech, 2020 - Springer
Mucuna pruriens (Mp) is an annual and perennial legume which belongs to the family
Fabaceae having different types of therapeutic activity. Anti-oxidative, anti-inflammatory, anti …

Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids

V Hernandez-Gordillo, T Kassis, A Lampejo, GH Choi… - Biomaterials, 2020 - Elsevier
Epithelial organoids derived from human donor tissues are important tools in fields ranging
from regenerative medicine to drug discovery. Organoid culture requires expansion of …

Recent advances in organoid development and applications in disease modeling

S Rauth, S Karmakar, SK Batra… - Biochimica et Biophysica …, 2021 - Elsevier
An improved understanding of stem cell niches, organogenesis, and disease models has
paved the way for developing a three-dimensional (3D) organoid culture system. Organoid …