Translation—a tug of war during viral infection

B Rozman, T Fisher, N Stern-Ginossar - Molecular cell, 2023 - cell.com
Viral reproduction is contingent on viral protein synthesis that relies on the host ribosomes.
As such, viruses have evolved remarkable strategies to hijack the host translational …

Advances and opportunities in methods to study protein translation-A review

D Zhang, Y Gao, L Zhu, Y Wang, P Li - International Journal of Biological …, 2024 - Elsevier
It is generally believed that the regulation of gene expression involves protein translation
occurring before RNA transcription. Therefore, it is crucial to investigate protein translation …

Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex

Y Matsuo, T Uchihashi, T Inada - Nature Communications, 2023 - nature.com
The collision sensor Hel2 specifically recognizes colliding ribosomes and ubiquitinates the
ribosomal protein uS10, leading to noncanonical subunit dissociation by the ribosome …

CMPK2 restricts Zika virus replication by inhibiting viral translation

JB Pawlak, JCC Hsu, H Xia, P Han, HW Suh… - PLoS …, 2023 - journals.plos.org
Flaviviruses continue to emerge as global health threats. There are currently no Food and
Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore …

RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages

TT Susanto, V Hung, AG Levine, Y Chen, CH Kerr… - Molecular Cell, 2024 - cell.com
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated
proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of …

Dysregulated ribosome quality control in human diseases

T McGirr, O Onar, SM Jafarnejad - The FEBS Journal, 2024 - Wiley Online Library
Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …

Run, Ribosome, Run: From compromised translation to human health

AC Vind, G Snieckute, S Bekker-Jensen… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Translation is an essential cellular process, and diverse signaling pathways
have evolved to deal with problems arising during translation. Erroneous stalls and …

Co-translational quality control induced by translational arrest

Y Matsuo, T Inada - Biomolecules, 2023 - mdpi.com
Genetic mutations, mRNA processing errors, and lack of availability of charged tRNAs
sometimes slow down or completely stall translating ribosomes. Since an incomplete …

The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation

D Machmouchi, MP Courageot, E Ogire… - PLoS Neglected …, 2024 - journals.plos.org
Mosquito-borne Zika virus (ZIKV) from sub-Saharan Africa has recently gained attention due
to its epidemic potential and its capacity to be highly teratogenic. To improve our knowledge …

Unexpected regulatory functions of cyprinid Viperin on inflammation and metabolism

L Chaumont, L Jouneau, F Huetz, DR van Muilekom… - BMC genomics, 2024 - Springer
Background Viperin, also known as radical S-adenosyl-methionine domain containing
protein 2 (RSAD2), is an interferon-inducible protein that is involved in the innate immune …