Translation—a tug of war during viral infection
B Rozman, T Fisher, N Stern-Ginossar - Molecular cell, 2023 - cell.com
Viral reproduction is contingent on viral protein synthesis that relies on the host ribosomes.
As such, viruses have evolved remarkable strategies to hijack the host translational …
As such, viruses have evolved remarkable strategies to hijack the host translational …
Advances and opportunities in methods to study protein translation-A review
D Zhang, Y Gao, L Zhu, Y Wang, P Li - International Journal of Biological …, 2024 - Elsevier
It is generally believed that the regulation of gene expression involves protein translation
occurring before RNA transcription. Therefore, it is crucial to investigate protein translation …
occurring before RNA transcription. Therefore, it is crucial to investigate protein translation …
Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex
Y Matsuo, T Uchihashi, T Inada - Nature Communications, 2023 - nature.com
The collision sensor Hel2 specifically recognizes colliding ribosomes and ubiquitinates the
ribosomal protein uS10, leading to noncanonical subunit dissociation by the ribosome …
ribosomal protein uS10, leading to noncanonical subunit dissociation by the ribosome …
CMPK2 restricts Zika virus replication by inhibiting viral translation
Flaviviruses continue to emerge as global health threats. There are currently no Food and
Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore …
Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore …
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated
proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of …
proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of …
Dysregulated ribosome quality control in human diseases
T McGirr, O Onar, SM Jafarnejad - The FEBS Journal, 2024 - Wiley Online Library
Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …
Run, Ribosome, Run: From compromised translation to human health
AC Vind, G Snieckute, S Bekker-Jensen… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Translation is an essential cellular process, and diverse signaling pathways
have evolved to deal with problems arising during translation. Erroneous stalls and …
have evolved to deal with problems arising during translation. Erroneous stalls and …
Co-translational quality control induced by translational arrest
Y Matsuo, T Inada - Biomolecules, 2023 - mdpi.com
Genetic mutations, mRNA processing errors, and lack of availability of charged tRNAs
sometimes slow down or completely stall translating ribosomes. Since an incomplete …
sometimes slow down or completely stall translating ribosomes. Since an incomplete …
The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation
D Machmouchi, MP Courageot, E Ogire… - PLoS Neglected …, 2024 - journals.plos.org
Mosquito-borne Zika virus (ZIKV) from sub-Saharan Africa has recently gained attention due
to its epidemic potential and its capacity to be highly teratogenic. To improve our knowledge …
to its epidemic potential and its capacity to be highly teratogenic. To improve our knowledge …
Unexpected regulatory functions of cyprinid Viperin on inflammation and metabolism
L Chaumont, L Jouneau, F Huetz, DR van Muilekom… - BMC genomics, 2024 - Springer
Background Viperin, also known as radical S-adenosyl-methionine domain containing
protein 2 (RSAD2), is an interferon-inducible protein that is involved in the innate immune …
protein 2 (RSAD2), is an interferon-inducible protein that is involved in the innate immune …