SARS-CoV-2: an overview of the genetic profile and vaccine effectiveness of the five variants of concern

R Dumache, A Enache, I Macasoi, CA Dehelean… - Pathogens, 2022 - mdpi.com
With the onset of the COVID-19 pandemic, enormous efforts have been made to understand
the genus SARS-CoV-2. Due to the high rate of global transmission, mutations in the viral …

Spatial and temporal distribution of SARS-CoV-2 diversity circulating in wastewater

A Pérez-Cataluña, Á Chiner-Oms, E Cuevas-Ferrando… - Water Research, 2022 - Elsevier
Wastewater-based epidemiology (WBE) has proven to be an effective tool for
epidemiological surveillance of SARS-CoV-2 during the current COVID-19 pandemic …

Molnupiravir maintains antiviral activity against SARS-CoV-2 variants and exhibits a high barrier to the development of resistance

JM Strizki, JM Gaspar, JA Howe… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Molnupiravir, an oral prodrug of N-hydroxycytidine (NHC), previously demonstrated broad in
vitro antiviral activity against multiple RNA viruses and has shown a high barrier to the …

Structural and biochemical characteristics of mRNA nanoparticles determine anti–SARS-CoV-2 humoral and cellular immune responses

Y Shi, J Huang, Y Liu, J Liu, X Guo, J Li, L Gong… - Science …, 2022 - science.org
The coronavirus disease 2019 (COVID-19) pandemic underlines the urgent need for
effective mRNA vaccines. However, current understanding of the immunological outcomes …

The central role of extracellular vesicles in the mechanisms of thrombosis in COVID-19 patients with cancer and therapeutic strategies

H Jing, N Zuo, VA Novakovic, J Shi - Frontiers in Cell and …, 2022 - frontiersin.org
Cancer patients have increased SARS-CoV-2 susceptibility and are prone to developing
severe COVID-19 infections. The incidence of venous thrombosis is approximately 20% in …

Missense mutations in spike protein of SARS‐CoV‐2 delta variant contribute to the alteration in viral structure and interaction with hACE2 receptor

TB Mahmood, MI Hossan, S Mahmud… - Immunity …, 2022 - Wiley Online Library
Introduction Many of the global pandemics threaten human existence over the decades
among which coronavirus disease (COVID‐19) is the newest exposure circulating …

Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging …

A Tahsin, R Ahmed, P Bhattacharjee, M Adiba… - Computers in Biology …, 2022 - Elsevier
Since the emergence of SARS-CoV-2 at Wuhan in the Hubei province of China in 2019, the
virus has accumulated various mutations, giving rise to many variants. According to the …

[HTML][HTML] Full-genome sequencing and mutation analysis of SARS-CoV-2 isolated from Makassar, South Sulawesi, Indonesia

MN Massi, RS Abidin, AEA Farouk, H Halik, GV Soraya… - PeerJ, 2022 - peerj.com
Methods Data were collected from 50 full-genome sequences of SARS-CoV-2 isolates from
Makassar, South Sulawesi, Indonesia. Mutation and phylogenetic analysis was performed of …

[HTML][HTML] Quercetin: A promising drug candidate against the potential SARS-CoV-2-Spike mutants with high viral infectivity

B Pan, S Fang, L Wang, Z Pan, M Li, L Liu - Computational and Structural …, 2023 - Elsevier
The emergence of SARS-CoV-2-Spike mutants not only enhances viral infectivity but also
lead to treatment failure. Gaining a comprehensive understanding of the molecular binding …

APOBEC3-related mutations in the spike protein-encoding region facilitate SARS-CoV-2 evolution

J Shen, X Xu, J Fan, H Chen, Y Zhao, W Huang, W Liu… - Heliyon, 2024 - cell.com
SARS-CoV-2 evolves gradually to cause COVID-19 epidemic. One of driving forces of SARS-
CoV-2 evolution might be activation of apolipoprotein B mRNA editing catalytic subunit-like …