The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques,
neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the …

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes
in bone biology, particularly to intramembranous ossification, not captured at other skeletal …

Human biological aging from maturity to senescence is associated with a gradual loss of
muscle mass and neuromuscular function. It is not until very old age (> 80 years) however …

Gyrification of the cerebral cortex changes with aging and relates to development of
cognitive function during early life and midlife. Little is known about how gyrification relates …

Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …

Introduction Both late-onset Alzheimer's disease (AD) and ageing have a strong genetic
component. In each case, many associated variants have been discovered, but how much …

Background and Objectives Previous studies suggest that lower mitochondrial DNA
(mtDNA) copy number (CN) is associated with neurodegenerative diseases. However …

Here we review the motivation for creating the enhancing neuroimaging genetics through
meta‐analysis (ENIGMA) Consortium and the genetic analyses undertaken by the …

Copy Number Variants (CNVs) are associated with elevated rates of neuropsychiatric
disorders. A 'genetics-first'approach, involving the CNV effects on the brain, irrespective of …