Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …

Neuroinflammation is a central mechanism involved in neurodegeneration as observed in
Alzheimer's disease (AD), the most prevalent form of neurodegenerative disease …

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …

For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand
for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and …