Cellular and molecular mechanisms of allergic asthma
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
Short chain fatty acid metabolism in relation to gut microbiota and genetic variability
It is widely accepted that the gut microbiota plays a significant role in modulating
inflammatory and immune responses of their host. In recent years, the host-microbiota …
inflammatory and immune responses of their host. In recent years, the host-microbiota …
Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease
STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …
Decoding the genetic and epigenetic basis of asthma
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
[PDF][PDF] Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk
Transcriptomics data have been integrated with genome-wide association studies (GWASs)
to help understand disease/trait molecular mechanisms. The utility of metabolomics …
to help understand disease/trait molecular mechanisms. The utility of metabolomics …
Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
SP Sajuthi, JL Everman, ND Jackson, B Saef… - Nature …, 2022 - nature.com
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide
association study for asthma by combining RNA-seq data from the nasal airway epithelium …
association study for asthma by combining RNA-seq data from the nasal airway epithelium …
Transcriptome-wide association studies: recent advances in methods, applications and available databases
Genome-wide association study has identified fruitful variants impacting heritable traits.
Nevertheless, identifying critical genes underlying those significant variants has been a …
Nevertheless, identifying critical genes underlying those significant variants has been a …
Mendelian randomization analysis reveals a complex genetic interplay among atopic dermatitis, asthma, and gastroesophageal reflux disease
K Ahn, RB Penn, S Rattan, RA Panettieri Jr… - American journal of …, 2023 - atsjournals.org
Rationale: Gastroesophageal reflux disease (GERD) is commonly associated with atopic
disorders, but cause–effect relationships remain unclear. Objectives: We applied Mendelian …
disorders, but cause–effect relationships remain unclear. Objectives: We applied Mendelian …
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
W Xie, J Li, H Du, J Xia - Arthritis Research & Therapy, 2023 - Springer
Background In addition to decreasing the level of cholesterol, proprotein convertase subtilis
kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the …
kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the …
Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …